Some sort of drug is usually acceptable culturally. Alcohol, very widely. Cannabis, more recently. Mild drugs like coffee. "Prescribed recreationals" like xanax in some circles. In many places Hashish or opium are still seen as traditional/acceptable.

I grew up in Israel, where qat is legal, seen as equivalent to coffee and culturally acceptable. It's fairly common as an ornamental plant.

Giving your cat whiskey would cause an uproar, but I guess catnip gets a grandfather exception.