Backspace is one of the top three most used keys for common computer usage, putting it on the thumb is a huge win over the corner to be used with the pinky (or a Shift, Control, Enter, etc.). The layout is otherwise fairly conservative with dedicated function keys, arrow keys, and navigation keys (albeit in a non-standard cluster).
[1] see key layout and mapping: http://www.keyboard-layout-editor.com/#/gists/8ec5e9026d616e...