The drug: https://en.wikipedia.org/wiki/Viloxazine
tl;dr: It's an SNRI, like Effexor or Cymbalta.
tl;dr: It's an SNRI, like Effexor or Cymbalta.
BTW unrelated but simultaneously taking SSRIs with stimulants show great results (but there are few studies) (of course don't overdose if you don't want serotonine syndrome)
And no it does not cause the release of any monoamine, when they are released they can stay longer in the brain before being garbage collected which virtually increase their density. It is an unknown whether delayed this garbage collection cycle accelerate ageing or other side effects.
Amphetamine is a releasing agent too.
Different drugs have different receptor affinities. And the different metabolites do too.
Amphetamine is a releasing agent too good point but this additional aspect aside, dextroamphetamine should have the same antidepressant effect as Wellbutrin and I don't think that is the case, for an unknown reason.
Different drugs have different receptor affinities. Oh I thought Adderall was non-selective (affecting all receptors) but I might be wrong and that would be a possible explanation!
And the different metabolites do too. I don't know what this can imply.
No 2 drugs are exactly alike. Their different metabolites also have their own effects.
The mechanism of action section specifically says that it did not block norepinephrine reuptake in the studied brains of rats (only in heart tissues) and that the serotonin reuptake inhibition was very weak. The mechanism of action is more complex, involving 5-HT2B antagonism and 5-HT2C agonism and some downstream upregulation of GABA-B in certain brain areas. It's likely there are additional mechanisms that are not fully understood yet.
tl;dr: It's nothing like an SNRI like Effexor or Cymbalta. Always defer to actual patient outcomes in clinical studies instead of trying to infer a drug's effects based on binding affinities.
The only reason it even really comes up is the OMG stimulants are evil crowd who don’t want to even look at the reality of the situation.
> it’s clear this should be unethical to prescribe for anyone stimulants would be effective on.
This is wrong in so many ways. Again, please don't try to guess outcomes based on binding affinities.
For what it's worth, some of the non-stimulant ADHD medications such as Guanfacine are strikingly effective for ADHD when titrated properly, some times even moreso than traditional stimulants. The challenge is that titration can take time and the effects are not immediately apparent from the first dose, whereas stimulant medication follows the opposite trajectory where the first dose is the most effective and subsequent dosing has reduced effects due to tolerance. Parents often mistake the instant response of stimulants for superior efficacy in treating ADHD, whereas instrumented tests show that medications like Guanfacine are actually quite good if the patient is given time to adapt.
Ironically these are all things people think Adderall does which it doesn't do.
For instance - stimulants in ADHD populations do not cause suicidal ideation. Which is nice. This drug does for a non trivial number of folks who get it.
I can't wait until 2041 when this is phased out and we get "esviloxazine" for $300+/month.