I'm Chilean and I use the ANSI US layout because /, < and > are much easier to type than using ISO keyboards.
When I need to type Spanish characters like áéíóú, ñ, etc. I switch to latin american ISO layout using WIN + Spacebar and then switch back.
When I need to type Spanish characters like áéíóú, ñ, etc. I switch to latin american ISO layout using WIN + Spacebar and then switch back.
I have a strange ISO/ANSI US keyboard, with an ANSI left shift and an ISO enter key.
Trying to remember more than two layouts becomes confusing very fast. AZERTY and QWERZ are the two worst ones, fortunately I never need to use those.
These keys are present on the UK keyboard, but not the US: £¬
Compared to every other common ISO keyboard layout, ISO UK and ANSI are very similar. For non-programmers, ", @ and (nowadays) # are the ones that matter. For a programmer used to an ISO keyboard, the UK layout may well be a better choice than the US ANSI one. (US ISO would be a good choice, but the extra key seems to duplicate symbols already present on the layout).