Current releases of the Librem 5 have been plagued by thermal throttling issues and poor battery life which in some cases has clocked in at less than 1 hour at idle.
The Librem 5 does not even support software encryption and no progress has been made toward adding even LUKS encryption. The Librem 5 lacks a secure element for any hardware binding on the encryption and so would be entirely dependent on software-only encryption.
The rebranded version of Debian that the Librem 5 uses as an operating system uses the same security model as the desktop stack, which is a perimeter or "all or nothing" security model. In the future, applications may be installed utilizing FlatPak. The threat model and measures FlatPak takes to meet it are as of yet unclear and uncertain.
From https://github.com/Peter-Easton/GrapheneOS-Knowledge/blob/ma... which may be mildly out of date — but I doubt it.
tl;dr Wake me up when you have an IOMMU!