Honestly I don't know and I think I should. I have uBlock Origin, Privacy Badger, ClearURLs installed on Firefox, I'm running pi-hole at home, it's just so much.
Privacy badger is largely useless ever since they got rid of heuristics. ClearURLs is useful, but you'd probably be fine without it. And pi-hole doesn't block anything that uBo doesn't in Firefox (but is still useful for applications outside of the browser).
On the other hand, maybe you're like me and want to squeeze as much privacy out of your browser as you can, even if it means breaking some websites. If that's the case, check this website out. Just remember that the tweaks listed here are nice, but not entirely necessary.