Buddy of mine did his master thesis as at a biofuel company a decade ago or so. He was supposed to do some advanced filter modelling, but do so he needed to configure the pid regulators to actually save the sensor values, not to mention turn them on. So he ran the pid configuration software, noticed they hadnt been tuned at all, set the values to something not catastrophically shit by just looking at the signals for a few minutes, then collected his data the next few days and went home to work on the thesis. It took a month before they figured out the random thesis worker no one paid attention too was the reason output was up 80%. He got a really nice bonus and job offer as a result. Then he actually tuned the pids using basic but proper system identification, but the largest gain is always from the most basic stuff, like turning the controllers on.