Sure, that's trivial, the travelling salesman problem for example can't be solved exactly, but approximative methods come very close. Given that brains are pattern recognition machines generating probabilities we're already in the approximative regime. Nothing is certain, even science has its revisions.
So does it matter if we can only approximate? For living things the main thing that matters is life, self reproduction, not exactness. As long as they reproduce they are still valid, with all imperfections and approximations. I think the only questions that matter are those related to life, there are plenty of uncomputable things outside self reproduction. This is for biological agents, an AI would be using evolutionary methods to reproduce their digital genes instead.