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Most end-users are on Windows, however.

That may not be the case for much longer. The press release on their final financial report from last year:

https://nvidianews.nvidia.com/news/nvidia-announces-financia...

Data center revenue at $6.7 billion. Gaming at $7.7 billion. But data center grew 124%, gaming 41%. If that keeps up, data center passes gaming this year.

I don't think data centers count as end users. End users are human beings that use a system.

That doesn't make any sense to me. Human ML/AI researchers are also users and NVIDIA clearly intentionally targets them as a market segment. They don't only care about pleasing gamers running Windows.

in the context of a desktop app, it seems pretty clear 'alphachloride was referring to desktop users.

how is the existence of big datacenters relevant to what platforms nvidia will support for a desktop app?

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