Why do you believe that a higher entity would care at all about your suffering? Why would they step in and intervene? You’re projecting human qualities (empathy, caring) on something you know nothing about, but which certainly isn’t human.
Just choose a disease and go for a 10 minute Wikipedia rabbit hole.
If cruelty exists in their world, then empathy and caring must exist too.
I can't explain why its insignificant, of course. It's like a hydrocarbon combusting in your car engine, and the rest of the little molecules wondering what kind of a monster could do that to them. We humans aren't even aware that it could be a problem.