its use in places that don't have enough doses to go around would be huge though.
> the 30µg of genetic material in the Pfizer/BioNTech vaccine vs. closer to 100µg in Moderna's indicates to me that their RNA optimization was probably superior, and is likely part of the reason for the less severe side effects
https://www.reddit.com/r/medicine/comments/kp1a00/moderna_vs...
> Moderna probably used a higher dose than they needed to. This was discussed with the vaccine advisory committee. Apparently the dose they settled on for phase 3 trials was decided prior to having all the phase 2 data. They decided to error on the side of effectiveness when they picked the current dose. They basically admitted, if they knew then what they know now, they probably would have used a lower dose in phase 3.
so basically 6 months ago they knew it was probably too much
as to why the pfizer is effective against the delta it's probably just picking the right sequence that is slightly closer to the delta by chance.
The encoded spike protein in Pfizer and Moderna is identical,[0] so it's probably not going to be that.
It could be a difference in the mRNA encoding leading to better transcription by our cells, or something to do with the nanoparticles used to smuggle in the mRNA.
[0] https://twitter.com/adamjmacneil/status/1407019597757390850
It's likely that had this strategy been done 6 months ago, a large number of dead people would be alive today.
The only major downside is the population may come to believe the 'vaccine' is ineffective and not trust future vaccination efforts.