Some reasons: they're not addictive, one intense sitting can have fully transformative effects, people might return to them a couple of times in their life (e.g. the exact opposite of most of commercial drugs).

also, scalable profit needs repeat interactions and growth in consumption. Neither of these are healthy in regard to psychedelics. The outcome of that could just be a slightly funky prozac thats as watered down in its effects as predecessors.

Decriminalisation, e.g. freedom to self cultivate and in use in long term medical trials is the best option imo.