Everyone knows that flying wings can be more fuel efficient. The problem is that putting passengers out further from the roll axis makes them airsick during turns. Cargo might be a better application.
I'd guess that turns aren't a big deal. Commercial flights rarely turn above 10k feet, so really just some risk of airsickness briefly at either end of the flight. Wing flex during turbulence seems like it would be a far bigger concern for passengers at the ends. That would not be a fun ride, but maybe these crafts handle chop differently? I'd imagine the flex is more evenly distributed, but still problematic.