I think web designers could stand to study actual grid based graphic design and see how that applies to our current capabilities on the web.

As for layout frameworks, I tried to learn them, but as far as I could tell they simply made bad/half assed design faster and easier. For a laughable amount of time they assumed you were building a desktop size column-based layout that was supposed to shrink, and anything different didn't work. So I never used them. It's fine if you're not hoping to produce a good design and just ship something generic, but idk if anything really good has come from them.