Opera's killer features get copied sooner or later (sessions, DOM cache, speed dial, undo close tab, etc.) And what is a killer depends what you care about…
• It's very good if you prefer using keyboard navigation (spatial navigation is a killer not copied anywhere yet)
• Mouse Gestures are still best implemented in Opera IMHO, although Apple's trackpad gestures make that less of a killer feature these days.
• (Fast)Forward button finds and "clicks" on links with labels like "Next page" which makes paged navigation easy.
• Opera handles lots of tabs in a session very well. I often leave tabs open instead of bookmarking pages :)
• The built-in mail client is a killer for me – has "GMail-like" filters (predating GMail), very good threading, 1-key shortcuts and differentiates between "seen" and "read".