Actually the only downside for me recently was not being able to share a DVD iso image recently due to the size limit on the free account, and looks like they fixed that problem now too. Contacts sync was a bit of a pain to get working but it works fine now.
But to answer your question partially (from Wikipedia):
> As of April 2011[update], Dropbox has more than 25 million users. [20]
I would guess most are not Linux users.
Also for more serious backup options people should probably use something like tarsnap.
EDIT:
Just found on their blog from February, they claim 2% Linux users. So around 0.5M I guess ...
Dropbox has always worked well for me and it's cross-platform so I can use it on my laptop also which runs Linux. I like to try Ubuntu One when start to hear more positive things about it and the Windows client comes out of beta.