I remember reading about an experiment that used genetic algorithms to evolve FPGA layouts to create circuits that achieved some task while minimizing transistor count. I think it might have been NASA trying to develop smaller, more sensitive radios, but I'm not sure. IIRC, they found that they could evolve novel circuits that could perform the task with far fewer transistors than traditional methods. But, they couldn't figure out how to transcribe it to an IC outside of the FPGA, as the circuits would stop working. There were also disconnected sections of the FPGA that the GA had evolved that didn't appear to contribute to the output, but couldn't be removed without again breaking the functionality. Obviously, there were some kind of crosstalk issues going on that the GA could minimax to a solution, but it was extremely brittle to change.
EDIT: I was completely wrong about the source and application. Can't believe I was able to find it, because I was way off. This was it: https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.50....
Other reading indicates that this technique has been successfully applied in electronics design in the time since 1996. https://en.m.wikipedia.org/wiki/Evolvable_hardware
The NASA thing I was thinking of was this: https://en.m.wikipedia.org/wiki/Evolved_antenna