Through the very same means, first thing I do with every new AWS-based project is setting up a cleanly organized Org with centralized billing, centralized IAM&Roles, centralized billing alarms, centralized SCP limitations(!!!) (as in “I will never run anything in Southeast Asia, so I disallow anything in Southeast Asia for all Org accounts), and very not-centralized resources per stage/subproject/vertical/whatever.
Plus sensible service limits on everything that has a service limit (request on API gateway etc.).
But as someone here said: your risk will remain > 0, you just have to accept that.