Sounds like "let's develop a healthier form of crack" to me.
Sounds like "let's develop a healthier form of crack" to me.
By healthy I would mean physically non addictive and without any negative long term effects. If you used it right it would just give you euphoria, motivation, stimulation and potentially nootropic effects?
But how would something like work? It's the substance's ability to cause euphoria that makes it addictive. You cannot have one without the other. Addiction occurs when one loses the ability to regulate their dopamine-driven activity, causing something akin to an infinite loop. Adderall is basically legal meth, and it's easily the most abused medication in the US.
There's 2 addictions, physical and psychological. Psychological, could yes still happen of course even if you restored the balance of dopamine and other relevant chemicals, but in theory you could at least get rid of withdrawals if you were able to manipulate those chemicals. We don't have a way to do that, and may be we won't have, and maybe we'll invent something completely different first that would make something like this or drugs completely obsolete. But just in theory.
I highly recommend reading the Molecule of More, which does an incredible job of explaining the brain chemistry behind addiction in an accessible way.
I think OP's really onto something here.
Maybe something to reset the brain chemical state in such way that tolerance and addiction could not come up. It surely must be possible in some way.
He ended up finding a handful of papers scattered across the last decades where people had come to the same realisation, but nothing came of it. Now, it's very possible there was something wrong with the idea. He did synthesise the molecule and we both took it, but not for long enough to really assess - even in a Shulgin-like way - whether it was addictive. But he ended up suspecting that the reason nothing came of it is that a non-addictive drug is simply not profitable, and is dominated, in the game-theory sense, by addictive drugs which bring consistent and greater revenue streams.
Also, apropos of:
> reset the brain chemical state in such way that tolerance and addiction could not come up
You may want to look into ibogaine. It doesn't give you both the high and the 'resetting the brain' functions - it only does the latter - but it's a very interesting case in that it has a very successful track record in resetting addiction. Though research is hampered by the fact that its cardiotoxic properties have killed a bunch of people who didn't do proper ECGs etc to check for heart abnormalities before taking it.