Especially easy with Vorta [1] and hosted on BorgBase [2]. It's definitely for the technically literate user, but if you are, then it's a dream, and the tutorials by borgbase are super nice.

I was searching for something the could replace Backblaze on Linux for me, and Vorta+BorgBase was even better than that.

Encrypted and compressed by default, deduplicated, life-long (if desired) and diffable history, every snapshot can be mounted locally, alerts on missing backups, just a breeze to use, and works for my personal machines just like my VPS.

[1]: https://vorta.borgbase.com/

[2]: https://borgbase.com/