Yes, if my feed is composed entire of accounts I follow sorted by date descending, there is little to no opportunity nor incentive for bots to exist at all. Sure, our proverbial crazy uncle is still going to send out conspiracy theories to everyone in his contacts, but this has existed forever and never seemed to cause that much trouble compared to algorithmic newsfeeds.
Even if you include results from followed topics sorted by explicit upvotes, so long as there's none of these inferred engagement metrics used in ranking then the blast radius of a malicious account will be severely limited as it's a lot harder to game explicitly expressed user intent.