From a productivity and ergonomics perspective, I don't think chip level simulation would be the way two go. First, Genera has been ported forward to new system. First OpenGenera was released for Tru/64 on the DEC Alpha platform as an official product. The fastest Symbolics hardware was about 6 times faster than the original Symbolics hardware. OpenGenera on a 533mhz Alpha was about 3 times faster still. There is a project called VLM to let you run OpenGenera on x86 or ARM and I would imagine it is many times faster still. Also, to my understanding, OpenGenera can still be purchased from symbolics-dks.com for a heft fee.
Second, I think that productivity will be limited by how much it is stuck in the past. If nothing else, crypto being behind the times seems likely to be an issue with networking with the rest of the world.
I would love to see a more modern system like OpenGenera. I also would love to see Symbolics style keyboards be made and possibly upgraded with things like better keyswitches and USB. That should be doable for someone who wants to make a custom layout, circuit board for that layout, and keycaps but based on QMK compatible hardware.