This has been tried before, with disappointing results, which is why I'm reluctant to put much effort into it myself. In 1999 Greg Stein (with Mark Hammond?) produced a fork of Python (1.5 I believe) that removed the GIL, replacing it with fine-grained locks on all mutable data structures. He also submitted patches that removed many of the reliances on global mutable data structures, which I accepted. However, after benchmarking, it was shown that even on the platform with the fastest locking primitive (Windows at the time) it slowed down single-threaded execution nearly two-fold, meaning that on two CPUs, you could get just a little more work done without the GIL than on a single CPU with the GIL.