There's definitely a much bigger risk with an intermediate on the internet, however we at least have the mitigation of being able to revoke it if it goes wonky, the main priorities I see in this space are: (1) minimising the chance of a compromise as much as possible (very clear and well defined communication channels so that as few things are open to even being poked at for vulnz over the network as possible) and (2) being ready to react if there is a compromise (revoke the cert and recover)