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There was a really good Reply All about this. Not gonna spoil it:

And famously there was the Iterable CEO that was fired for microdosing: https://fortune.com/2021/04/28/justin-zhu-iterable-lsd-micro...

He "tried microdosing" immediately before a meeting with investors. He'd never used LSD before, and was visibly intoxicated.

And accidentally full dosed.