> Nix/Guix seems like the only one that's trying something different enough to address some of those other use-cases, but the cat's out of the bag for most people.
Maybe that's because nix and guix don't interop despite having rather similar principles, and because we mostly don't have GUI for it (like GNOME Software has integration for flatpak) nor desktop integration (like AppImageLauncher). Are you aware of work being done in this space?