I'm skeptic when it comes to anti-depressants because of their Post-SSRI sexual dysfunction effects http://en.wikipedia.org/wiki/Post-SSRI_sexual_dysfunction
The only drug I know that has no dangerous post conditions is St john's wort
Or is that that an insubstantial number of studies on St John's Wort have been carried out?
When I tried to find out about this (years ago, pre-Wikipedia I think) I couldn't find any substantive research.
For all their faults, pharmaceutical products are well-studied, especially the ones that have been on the market for some time.