The ghastly Helios accident [1] was also triggered by a misconfiguration (by maintenance staff). Sure, you’ll tell the pilots again to actually run their checklists, but you’ll also tell the maintenance crew not to screw up the standard settings.
Counterpoint: if you have a checklist item, and it is always in the desired/expected configuration already, you might start to skip it (with the concomitant consequences if one day it isn’t).
Maybe flight crews/maintenance staff should configure the machine randomly after a flight/maintenance, so as to force the next crew to actually run the checklist carefully?