This reminds me of one of the hardest lessons I ever learnt from college worksheets. We were asked whether a cell’s ribosomes fit in the cell normally or if they required compression of some sort. Subtracting the total volume of ribosomes in a cell from the total volume of the cell itself, we got a negative number, and indicated there must be some sort of compression.
Almost everyone got marked wrong. A simple difference, lacking context, is not a useful measure. What we should have calculated was a ratio.
It seemed arbitrary, but the entire class was a crash course towards scientific writing and everything was graded as if up for review. Picking the right metrics, assumptions, and descriptive language was crucial.