This paper inspired another fun followup: "Could a Neuroscientist Understand a Microprocessor?" [0] The authors investigated a 6502 running Atari games using popular neuroscience methods, finding things like transistors that are uniquely necessary to run Space Invaders, but, of course, never getting close to an actual understanding of how the processor functions. It really highlights how even with the huge amounts of data we are able to get from biological systems now, there's still a lot of information we paradigmatically can't understand.

[0]: https://journals.plos.org/ploscompbiol/article?id=10.1371/jo...