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Metformin is not ideal for some if not most men. It wipes out testosterone levels.

After a few weeks of taking it my T levels were below average and free-T levels were that of 100 year old men. This was a huge drop from the above average levels, for men in 20s, that I usually have.

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I’ve had the same experience. Feel like shit every time I get hopped up on the latest paper and try it again. I don’t want to live forever with T levels of an old man. I thought maybe I was the only one feeling this way, although I had seen the papers about it lowering testosterone.

[0] might be relevant to you, seen other papers that I found when I discovered this issue. From what I gathered the reason for this is that metformin reduces blood cholesterol levels which are important for testosterone production.

[0]: https://pubmed.ncbi.nlm.nih.gov/11707532/

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