Agree with sibling comment - the JS ecosystem has a huge momentum behind it and probably isn't going away anytime soon.
On the web, Wasm has currently found the most success with compute-intensive applications, since the JS <-> Wasm bridge is still pretty expensive. There are already some Wasm-based frameworks like https://platform.uno/ that work on the web, but things like React/React-native and Flutter have a huge head start.