There will never be new genres or art or music. Everything has been discovered already. Like colours, they are all already known. Sure you can have a new take something or maybe discover a new subgenre, but the majority is already there. And just because a genre would have a new "name" (just a branding thing anyway) doesn't mean it's not part of some other genre already.
You can't capture psychedelic and or mystic experiences, which are very subjective anyway and yes, rooted in _reality_ or require a reference to _reality_ as they are the so far away from that.