Have you ever had a methylation profile done? Would highly recommend it. https://www.doctorsdata.com/methylation-profile-plasma/
It is true that a small subset of people can have a certain set of mutations that has clinical significance, but the alternative medicine community has been hard at work trying to expand this condition to cover far more people than it actually does.
One common trick is to perform as many tests as possible, along with as many permutations of those tests (e.g. the various ratios between values). The more tests you conduct, the easier it is to find one that might be out of a specific range and therefore convince the purchaser that the test was worthwhile. If you really wanted to test something, you'd skip this test and get a cheap genetic test to see your MTHFR variant (note: heterozygous is fine, no matter what the naturopaths try to tell you).
It's also common to claim a test has significance in every medical condition that people might be Googling. The test you linked is guilty of this, claiming to be "Useful for" everything from autism to birth defects to cancer, down syndrome, immune dysfunction, nutritional deficiencies, psychiatric disorders and more.
Any test that claims to be relevant to so many different medical conditions is a huge red flag.
Save your money. If you're curious, you can read more about how the whole "methylation" and MTHFR alternative medicine got so out of control because one naturopathic author pushed it so hard as an explanation for everything: https://www.mcgill.ca/oss/article/pseudoscience-reviews/gene...
There's another good article here about why this test isn't really warranted for most people: https://health.clevelandclinic.org/a-genetic-test-you-dont-n...
Cue the "but anecdotal experiences aren't valid" hyperbole.
> Any test that claims to be relevant to so many different medical conditions is a huge red flag.
How much do you understand about DNA methylation?
> If you really wanted to test something, you'd skip this test and get a cheap genetic test to see your MTHFR variant (note: heterozygous is fine, no matter what the naturopaths try to tell you).
Homozygous C677T still affects ~10% of caucasians but isn't sufficient in and of itself to show poor methylation. C677T only shows a predisposition to the problem. So you have it backwards on recommended tests.
Since not everyone knows where to find cheap genetic tests, I'll be a good neighbor and recommend Nebula Genomics + Promethease (with the exported raw data). Stay away from 23andme.
The mistake is promoting methylation quackery as the underlying cause of everything, as your link above did. It’s obvious quackery and the medical community unanimously agrees (see my references above).
I’m glad you found a specific help for your specific situation. Extending that to be a wide-scale affliction of the population is the mistake.
I hope everyone reading this thread takes time to review mainstream medical sources (not naturopathic authors, test peddling websites, or anecdotes)
The test I linked is the same one that I had taken, don’t judge a book by its cover.
It’s not a catch all for everything, that’s why I suggested a $200 test, not a $20 supplement.
> Extending that to be a wide-scale affliction of the population is the mistake.
The very real pandemic of not-my-problem-itis is what led to this, with Obamacare making it into a gasoline fire. Good for profits, bad for life expectancy.
> the medical community unanimously agrees (see my references above).
The whole premise of that Cleveland Clinic article is based on the idea that genetic testing costs thousands of dollars as it does under the AMA cartel prices. Mayo Clinic for example charges $7000 for a few dozen generic markers. The genetic test I suggested is $99, and you get the entire part of the genome that has variations among humans. I would agree with the article that you shouldn’t pay an arm and a leg for a single genetic marker, but that’s not what we are talking about here.
The idea is some people are genetically very low/poor methylaters so they’re methylation impaired. Generally the solution if found to be a poor methylater is to take forms of vitamins that are already methylated, like methylfolate
Other possible treatments are L-Methionine or S-Adenosyl-Methionine (SAMe), as was recommended in my personal case of a deficiency in "methionine adenosyltransferase" (https://en.wikipedia.org/wiki/S-Adenosylmethionine_synthetas...). If you are on a concurrent SSRI (as many with this problem tend to need), the L-Methionine is temporarily used in lieu of the SAMe in order to help wean off the SSRI without the risk of Serotonin Syndrome that comes with SAMe + SSRI combination.
I'm not a doctor, just someone who has this as a patient.