I have been recently porting to Python (with NumPy) some badly written C++ code. I was really shocked that the performance drops nearly 100 times (because of many nested loops).
NumPy working on PyPy would probably get me really near original performance. And it's not the advanced features I hope for -- ndarray and basic linalg operations is all I need to do my thesis.
Anyway guys, great job so far, looking forward to the future.