Aging is a complex process. Do not ignore something as big and heavy as skin. It is entirely possible that secretions from aged skin cells dysregulate other organs etc. Given that we have been judging a person's health by their skin for centuries, it probably reflects the internal state of the organism somehow.

It might not be the most vitally important but ignoring the single biggest organ we have seems like a mistake to be honest.

Skin is vital, as you need to deage veins.

We'd probably be able to grow and transplant bespoke organs for you before then.