I think that there will be a generational shift here - you are not going to train an SVP to use Python, but the next generation of SVPs might have more exposure and be willing to use Numpy in a Jupyter notebook.
And in the other direction - there is definitely scope to come up with an “Excel isomorphic” Python framework for data science. It’s fairly easy to generate an Excel sheet from Python computations, but maintaining bi-directionality is Hard, and would require restrictions on the Excel side. I think with the right UI, you could do this though.