I don't doubt that coffee and caffeine can exacerbate some things.

For me though, no (or at least, not yet). And I'm a fairly heavy coffee drinker (maybe not by HN standards?) - especially since adding fatherhood to the mix, I'm generally 2-6 espresso shots of coffee a day, and some work binges much more.

Having said all of that, a focus for me at present is reducing my coffee intake. I'd like to get back to having a few coffee-free days each week, because it currently takes me 2 coffees to get back to 'normal' each morning and that can't be healthy now or for the long term.