Two come to mind rather easily.
1) Someone that is going to commit suicide. Having a family that you actually care about would make killing yourself more complicated. Alone, someone alone could go through with the act without actually hurting anyone else.
2) Someone who's entirety of experiences with family have been... complicated. Just as a thought experiment; say someone raised raised a child by punching them hard enough to bruise or draw blood for every little slight, real or perceived. Then ensured that the child understood that they were being hit and injured out of love.
How would that child would view family after enduring that when they become a young adult?