I strongly disagree that Lisp syntax is straightforward. Racket/Scheme is decent, but Common Lisp and other Lisp-2's can be incredibly confusing. Having different value and function namespaces for symbols is complicated enough, but the worse problem is that the simple evaluation rules don't always apply.

The base case is simple enough, the symbol-function value of the first symbol in a list is looked up, the rest of the arguments are evaluated or self-evaluated, then passed in to the function. The problem is that when the first symbol is a macro, you need to remember which of the following arguments are evaluated, or taken as unevaluated forms. Anyone who thinks this is easier to parse because there's less syntax either has too little experience with Common Lisp, or is kidding themselves.