Most jobs require a huge time investment and a reliable schedule.
At least theoretically, you could accommodate children by only giving them small roles that require very infrequent time investment on their part, and a bunch of people keeping an eye on everything going on.
The question is whether such a thing can be worked out at all, or whether it's safer just to jinx the entire idea, reasoning that there will be too much rule breaking despite good intentions.
It's definitely going to depend on the country and legal system -- it seems in Russia there's a fair amount of series with child actors in them, and I wonder how well they're treated, because a long running series is definitely going to be very demanding even on adults.