Ireland? That is my envious observation of things Irish startups indicate they can do by the offers they make in EU markets. Before Brexit, UK and Ireland appeared to be able to payroll a worker in another EU country, now just Ireland. For Switzerland, we could recruit them to work here or contract them but we could not directly payroll a worker who permanently lived and worked outside Switzerland.

US Person problems? Those are just part of the annoyances the US will bring you if it becomes a meeting point through the logistics of the boss needing to go there in person more often. I've met people working in Switzerland for the FAANGs in a tier beyond the people who work out of Canada to get around US travel complications, for additional US made complications for traveling to Canada. An accidental US person by marriage who travels with their partner and has a different income situation might also find they needed to be counting days in the US for tax reasons, etc.

Many companies seem to end up dual homed in Ireland and the US and that seems to work. Personally, I would start with seeing what Ireland alone looks like and delay anything in the US if possible.