The practices CafePress had prior to its breach were clearly inadequate, and justifiably actionable. They authenticated users with password-equivalent "security questions", which they (of course) stored in clear text. Storing cleartext password reset secrets contravenes universal industry best practices, and, really, so does the use of "security questions" at all --- though many banks still do.
But requiring 2FA tokens is not a universal practice. Moreover, deployed over a whole userbase, it doesn't really address the concerns that lead to or were revealed by this breach. Managing 2FA for non-technical end users --- that's the kind CafePress serves --- is extraordinarily difficult. People lose tokens, 2FA codes are phishable, account recovery remains the most difficult problem in computer security, and so on.
So yes, it is weird to me to see the FTC suggest that the appropriate solution to a broken authentication system with security question is "make people use 2FA tokens". The universal best practice solution to the specific problem the security tokens solved is "password reset emails that prove custody of a trusted email account". The demand from the FTC exceeds that best practice. That's interesting, and so I called it out.
We don't know each other, so it probably bears saying that I am foursquare supportive of 2FA. I'm supportive of a lot of things the FTC would no doubt love to force companies to do (penetration testing in particular!)