possibly stupid question: generically, how would you suggest to start actually finding a problem in any industry?
Go to many conferences to find where the smartest people are and how they are fixing the hardest problems. Meet the important people everyone knows in the industry who can help you navigate it.
Get to the top 1% in one of the skills which is critically important to your industry, so you can grok opportunities before others.
That might get you to the starting point. You can't just google "howto disrupt space".