If you just have a need for isolating Windows applications have you tried the Windows Sandbox functionality built-in to Windows 10 Pro and Enterprise version?
https://docs.microsoft.com/en-us/windows/security/threat-pro...
Open the .wsb (1 click) then open the PDF (1 or 2 clicks). When you're finished close the windows sandbox window and it'll all be gone.
But yes that is a great idea.
Windows Sandbox starts in like 8 seconds to be usable and is trashed when you close it.
So its far from useless.
But for your usecase, yes it wont work.