How does one build a canal that moves water uphill for 1500 miles across the continental divide in these quantities? If not a canal, then how do we do it? Pipes?
We're talking a million cubic feet per second in the Colorado river during high times, which has been completely drained and diverted by communities downstream.
The keystone pipeline carries 50 cubic feet per second. The largest pipeline in the world carries 1.5x that. Nowhere close to what a functional river provides.
So, either antigravity so the Mississippi flows uphill, or 20,000 keystone pipelines.
Desalination plus local pumping is much, much less science fiction.