We used to store 20-30mb of animation data with it and we'd just mmap the whole file and let the kernel handle paging it in/out, worked great.
I don't know how up to date their benchmarks[2] are but my experience has been that it beats almost every other off-the-shelf solution(other than maybe capn-proto which has some similar properties).
[1] https://google.github.io/flatbuffers/
[2] https://google.github.io/flatbuffers/flatbuffers_benchmarks....