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Comment by evo_9 | Hacker News Reader

Been taking this for nearly 5 years. Shits the real deal. No pretending when you’re competing still against 20-something that barely washed out of their pro nhl career… but yeah not like being 55 and playing high level hockey is any sort of ‘proof’ around here (or my multiple sets of 20-25 pull-ups I do regularly and I could barely do 10 when I was 30).

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Before taking this, please read https://www.foundmyfitness.com/topics/nicotinamide-mononucle... and the possible link between NMN and increased cancer prevalence. I believe the research is still too early and there is a risk with this compound.

Look up Dr. Standfield on YouTube he has a great health channel on all this stuff and digs into everything including NMN/nr and all the backing metadata / Cochrane research papers…

This Dr. Stanfield? /s

"Molecules I Used To Take But Have Now Stopped

NMN:

I focus on stopping my NAD from declining by using Apigenin, Quercetin, Fisetin, Niacin, regular exercise, a great diet, periods of safe fasting, and restful sleep.

Since I’m 30, there’s not a reason for me to take NMN in addition to the above strategies at the moment.

As I enter my mid-30s, if my NAD levels are going down I will start taking NR.

At this stage, there is far more published human data on NR compared with NMN. NR also has its Generally Recognized As Safe (GRAS) certification from the FDA. For those reasons, I would start NR, and not NMN."

https://drstanfield.com/my-supplements/

Brad had a fallout with Sinclair and Sinclair blocked him on twitter for asking a question about NMN and it's risks.

Since that Brad has stopped taking NMN and also requests people not to.

That’s not 100% true, he recommends NR because there are human trials and NMN is still being studded. Also he won’t be adding either until he’s around 45-50 (he’s only in his 30s)

I had a one-on-one phone call with him Sunday (Dr. Standfield) and we discussed my experience with NMN vs NR and which was ideal for my situation. Long / short his review of my stack was summed up as ‘you are doing everything right stick with NMN.’ The only change was to switch from l-serine to glycine.

It is true Sinclair blocked him after he asked for clarion some of his research (so rude!).

thats good to hear. His messaging on youtube was bit ambigous and i thought he was requesting people to be off NMN

Do you also supplement it with anything else, such as TMG or another methyl group donor, as Sinclair recommends?

Also, if you don't mind, what is your dose per unit of body weight, frequency and/or delivery method (oral/sublingual)?

I do. Along with Apigenin, and a few other new molecules.

Sublingual.

What’s your dose and brand? Why NMN vs NR?

I take 250mg / day of NMN from NOVOS Labs (https://novoslabs.com/product/novos-boost/). I can't definitively say I feel the effects.

The site offers a nice write up on NMN: https://novoslabs.com/nicotinamide-mononucleotide-nmn-and-lo....

Also, what about NMN versus Niagen (Tru)? Also as I understand these molecule may be fragile, do you keep them in the fridge?

Niagen is a trade name for NR. So you're asking the same question.

I do put all the more advanced stuff in the fridge including NMN, NR, rapamycin, heavy molecular weight Hyaluronic Acid

I’ve been taking NR too on and off as well, in my experience it doesn’t seem to have much effect on my athletic performance. So for me I’m sticking with an NMN even though there’s more clinical studies on nr at the moment

These are great questions, I'd also like to know dose frequency.

1gram every morning except my rest day when I take rapamycin.

alivebyscience.com (they recently changed their name and I can’t remember how to spell it sorry ha ha)

If I had to guess, when you started taking it at 50 you were also exceptionally fit and healthy for your age. Would you invest that money in a supplement if you were already over the hill ?

According to Dr.Sinclair (referenced in another comment), the NMN most people buy is probably worthless given it isn't stable. I buy it anyway because I have no better option and it doesn't burden my budget.

True, I played high-level hockey my whole life. And have actively worked out at a very high level most of my life… However I noticed everything dropping off around 50 and nothing seem to curb that. Especially my on ice speed which used to be always in the mid-20s and had dropped to the upper teens…

After starting NMN particular my VO two max and on ice speed went back up to my norm and have remained the same and actually gone back up and he’s always 22 to 25 miles an hour, at least when I’m playing against other high-end talent…. Sorry for the Poor grammar working out and using voice Rec

How are you taking it? And what does it cost?

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