adoptee turned to hard drugs (opiods) in his teens. the opinion was: what do you expect, the father was an addict too. at the time I was shocked as I was so firmly in the nurture camp.
However the main risk factor for trying and then abusing opioids, for example, is trauma, typically but not only in childhood. Basically, it’s both nature and nurture, as most things are. Where the percentages lie for both, I don’t think we know yet.
For instance parents who have genes that increase impulsivity are more likely to e beat their kids exposing them to trauma, the kids are more likely to do dumb things that expose themselves to trauma, and the kids are more likely to do impulsive things like try drugs.
So it's hard to disentangle what portion of the effects of trauma are direct and which are confounds.