A recent start on this could be the NopSys/CogNos project, which built a standalone Smalltalk system on x86 a few years ago. There are GitHub repos[1,2,3] and a paper [4] where the authors write "there would certainly be much more work needed before one could consider deploying our system." The project seems to be inactive now.
1. https://github.com/nopsys/nopsys
2. https://github.com/nopsys/CogNOS